LiverTwin™ fuses multi-omics, ultrasound/MRI and longitudinal EHR data to generate a patient-specific digital twin for metabolic liver disease management.
Built on NVIDIA's healthcare stack: BioNeMo – NeMo – MONAI – Triton – Holoscan – Omniverse – FHIR & DICOM compatible.
MASLD affects over 100 million Americans and is severely underdiagnosed. Existing tools rely on single-modality data and fail to capture the complex, dynamic nature of liver disease.
Over 100 million Americans affected, but most cases go undetected until advanced stages
Current tools analyze data in isolation, missing critical cross-modal insights
Clinicians lack integrated insights, leaving them without comprehensive decision support
Our AI platform creates comprehensive digital twins that transform liver disease management
Integrates multi-omics, imaging, and EHR signals to create patient-specific digital representations that capture the full complexity of liver disease
Predicts disease trajectory and identifies intervention opportunities before symptoms appear, enabling proactive care management
Provides next-best actions with clear rationale, integrates into clinical workflows, and auto-documents notes for seamless care delivery
Built from the ground up for comprehensive, explainable, and scalable liver disease management
Seamlessly integrates omics, imaging, and clinical data for comprehensive insights that single-modality tools miss
Built on NVIDIA's AI stack for real-time processing and scalability, delivering insights at the speed of care
Provides transparent rationale and evidence citations, building clinician trust through interpretable AI
Flexible deployment from bedside ultrasound carts to enterprise cloud, adapting to your infrastructure needs
LiverTwin™ runs as secure, containerized micro-services across NVIDIA's healthcare stack
MONAI + VISTA-3D NIM – Automated liver segmentation and quantification for CT/MRI with state-of-the-art accuracy
MAISI NIM – Scanner-harmonized, privacy-preserving augmentation to improve model robustness across sites
Parabricks + RAPIDS-singlecell + BioNeMo – Minutes-level genomics pipelines and pathway-aware embeddings
NIM + Triton + NVIDIA AI Enterprise – Hardened inference with access controls, auditability, enterprise-grade support
"Why this matters: validated components, faster pilots, easier approvals."
Six integrated modules that work together to create comprehensive digital twins
Single-cell and bulk RNA/DNA encoders produce biological pathway embeddings that capture molecular signatures
2D/3D ultrasound & MRI encoders extract tissue-level signatures and structural patterns from medical imaging
Converts longitudinal EHR data into disease state embeddings that track patient progression over time
Cross-attention layers unify modalities into a comprehensive patient state representation
Generates time-evolving liver states and counterfactuals to predict disease progression scenarios
Summarizes findings, drafts notes/orders, and suggests next-best actions with clear clinical rationale
Four seamless steps from data ingestion to clinical action
FHIR/EHR, DICOM/PACS, secure omics pipelines
GPU pipelines convert each modality into embeddings
Generative model produces the digital twin and forecast
Recommendations & documentation delivered back to the EHR
Flexible deployment options for cloud and edge environments
FHIR/EHR, DICOM/PACS, secure omics pipelines
MONAI imaging encoders; Parabricks/RAPIDS-singlecell + BioNeMo for omics; NeMo for clinical text
Multimodal fusion + LiverTwin™ generative simulator packaged as NVIDIA NIM micro-services
Triton-backed inference with GPU auto-scaling
Clinician Agent drafts notes/orders and writes back to the EHR
Proven, standardized workflows that accelerate deployment and reduce integration risk
Standardized, reproducible pipelines for cohort-scale analysis with validated performance metrics
End-to-end workflows for scRNA-seq and spatial transcriptomics with automated quality control
Using proven blueprints shortens pilot timelines and reduces integration risk for hospital IT.
Seamless integration with existing healthcare infrastructure
FHIR R4/R5 compliance, SMART-on-FHIR app framework, Epic/Cerner/Allscripts integration
DICOM-compliant deployment with real-time data synchronization
Continuous data synchronization with existing clinical workflows
Enterprise-grade security and compliance for healthcare environments
Full compliance with healthcare privacy regulations
End-to-end encryption in transit and at rest
Granular permissions and access controls
Complete logging and monitoring capabilities
Privacy-preserving model training options
Validated drivers, RBAC, logging and enterprise-grade support on-prem or in the cloud
Rigorous testing and validation across all system components
CT/MRI liver segmentation (VISTA-initialised MONAI): Dice / HD95 scores, scanner mix and site generalisation
Ultrasound triage on edge (Holoscan IGX/Jetson): per-frame latency (ms), throughput (fps) and referral-score stability
Genomics turnaround (Parabricks pipelines): wall-clock time per sample and concordance vs CPU baselines
Single-cell/spatial embeddings: batch-effect robustness and downstream fibrosis-stage classification AUC
Clinical agent reliability: citation coverage, note-draft accuracy and clinician override rate
Transforming outcomes across the healthcare ecosystem
Proven results that transform patient outcomes and healthcare economics
Increase in early-stage detection rates
Reduction in time to hepatology referral
Adherence to care pathways
Avoided advanced-stage costs per 1,000 patients
Experience how LiverTwin™ can transform your approach to liver disease management and patient care.
Common questions about LiverTwin™ implementation and capabilities